The organization of lipids in biological membranes is essential for cellularfunctions such as signal transduction and membrane trafficking. A majorchallenge is how to control lateral lipid composition in supported membraneswhich are crucial for the design of biosensors and investigation of cellularprocesses. Here, we undertake the first theoretical study of lateralorganization of mixed lipids in bilayers induced by a geometrically patternedsubstrate, and examine the physical mechanism of patterned substrate-inducedstructural formation in the supported lipid bilayers. A rich variety ofcomposition segregations of lipids are regulated, and the results can accountwell for most recent experimental works [Yoon, T. Y. et al. \textit{Nat. Mater.} \textbf{5}, 281(2006) and Parthasarathy, R. et al.\textit{Langmuir} \textbf{22}, 5095(2006)]. The present study provides acomprehensive understanding of mechanically controlling the spatialorganization of membrane components by unifying these experimental evidences.
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机译：生物膜中脂质的组织对于细胞功能（例如信号转导和膜运输）至关重要。主要挑战是如何控制支撑膜中的侧脂成分，这对生物传感器的设计和细胞过程的研究至关重要。在这里，我们进行了由几何图案底物诱导的双层中混合脂质横向组织的首次理论研究，并研究了在支持的脂质双层中底物诱导的结构形成的物理机理。调节脂质的多种组成分离，其结果可以解释最近的实验工作[Yoon，T. Y. et al。 \ textit {Nat。 Mater。} \ textbf {5}，281（2006）和Parthasarathy，R.等人。\ textit {Langmuir} \ textbf {22}，5095（2006）]。本研究通过统一这些实验证据，对机械控制膜成分的空间组织提供了全面的了解。
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